Molecular Cell Differentiation Lab

    Academic advisor
    Professor Wan Su Choi Professor Wan Su Choi
    Lab introduction The Molecular and Cellular Differentiation Lab aims to discover new therapeutic targets by identifying the signaling system and regulatory mechanisms of degenerative musculoskeletal disorders and chronic inflammatory diseases. With this goal, we are deeply exploring the pathophysiology of diseases through a multifaceted approach, from molecular level research to clinical analysis using various disease animal models and actual patient samples. We are conducting research on the development of therapeutic agents that can actually treat diseases.
    Major research area
    1. Identification of mechanisms of degenerative and chronic inflammatory diseases caused by metabolic syndrome
    2. Identification of muscle diseases based on Omics and Protein-Protein Interaction (PPI)
    Major achievement
    • Major papers
      1. Choi WS, Lee G, Song WH, Koh JT, Yang J, Kwak JS, Kim HE, Kim SK, Son YO, Nam H, Jin I, Park ZY, Kim J, Park IY, Hong JI, Kim HA, Chun CH, Ryu JH, Chun JS. CH25H-CYP7B1-RORα axis of cholesterol metabolism regulates osteoarthritis. Nature 566: 254-258. 2019. [IF 43.070 1.56% 1/64 multidisplinary]
      2. Choi WS, Yang JI, Kim W, Kim HE, Kim SK, Won Y, Son YO, Chun CH, Chun JS. Critical role for arginase II in osteoarthritis pathogenesis. Ann Rheum Dis 78: 421-428. 2019 [IF 14.299 6.67% 2/30 Rheumatology]
      3. Choi WS, Chun JS. Upregulation of lipocalin-2 (LCN2) in osteoarthritic cartilage is not necessary for cartilage destruction in mice. Osteoarthritis Cartilage 25: 401-405. 2017. [IF 4.879 2.60% 2/77 Orthopedic]
      4. Son YO, Kim HE, Choi WS, Chun CH, Chun JS. RNA-binding protein ZFP36L1 regulates osteoarthritis by modulating members of the heat shock protein 70 family. Nat Commun 10:77. 2019. [IF 11.878 4.69% 3./64 multidisplinary]
      5. Park SH, Rhee J, Kim SK, Kang JA, Kwak JS, Son YO, Choi WS, Park SG, Chun JS. BATF regulates collagen-induced arthritis by regulating T helper cell differentiation. Arthritis Res Ther 20: 161. 2018. [IF 4.148 26.67% 8/30 Rheumatology]
      6. Son YO, Park S, Kwak JS, Won Y, Choi WS, Rhee J, Chun CH, Ryu JH, Kim DK, Choi HS, Chun JS. Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes. Nat Commun 8: 2133. 2017. [IF 11.878 4.69% 3./64 multidisplinary]
    Contact
    • Tel : 055-320-3481
    • E-mail : wansuchoi@inje.ac.kr