약제학 연구실

    지도교수
    최두형교수님 최두형
    실험실 소개 약제학 연구실은 QbD 기반으로 다양한 제형을 개발 및 평가하고 공정 Scale-up 전략에 대해 연구하고 있다.
    주요연구내용
    • QbD 기반 의약품 제형설계 및 공정최적화 연구
    • 메커니즘기반 모델 시뮬레이션을 이용한 공정 연구
    • 공정분석기술 (PAT)를 이용한 공정 스케일업 연구
    • 신규물질 preformulation 연구
    • Drug delivery system 개발 및 평가 연구
    주요실적 [대학원생 연구 활동]
    • <국제학회 및 교육 참석>
      • 2018 FREUND Seminar, Hamamatsu, Japan
      • 2018 ISPE Annual Meeting&Expo, Pennsylvania, PA, USA
      • 2018 EDEM Meeting, Edinburgh, UK
      • 2019 ISL-FD Conference, Ghent, Belgium
    • <논문>
      • 장*하 : Investigation of the effects of materials and dry granulation process on the mirabegron tablet by integrated QbD approach with multivariate analysis (Powder Technology, 2021)
      • 김*연 : Control Strategy for Process Development of High-Shear Wet Granulation and Roller Compaction to Prepare a Combination Drug Using Integrated Quality by Design, (Pharmaceutics, 2021)
      • 박*서 : Application of mechanism-based modeling to predict drug quality during the pharmaceutical unit operations of granulation and compression: A review, (Journal of Pharmaceutical Investigation, 2020)
      • 장*하 : Model-Based Scale-up Methodologies for Pharmaceutical Granulation, (Pharmaceutics, 2020)
      • 염*빈 : Application of the discrete element method for manufacturing process simulation in the pharmaceutical industry, (Pharmaceutics, 2019)
      • 염*빈 : Scale-up strategy in quality by design approach for pharmaceutical blending process with discrete element method simulation, (Pharmaceutics, 2019)
      • 이*빈 : Orally disintegrating films focusing on formulation, manufacturing process, and characterization, (Journal of Pharmaceutical Investigation, 2017)
      • 이*빈 : Formulation optimization and in vitro characterization of orally disintegrating films using a factorial design and mathematical modeling for drug release (Chemical and Pharmaceutical Bulletion, 2016)
    • <Poster 발표>
      • 김*지: Quality by Design(QbD) approach: Development of trasndermal patch system : a review, 2020 약제학회
      • 김*연: Integrated QbD approach for the development and control strategy of bilayer tablet by multivariate analysis, 2020 약제학회
      • 장*하 : A dynamic flowsheet simulation and global sensitivity analysis of a pharmaceutical high-shear wet granulation, 2019 약제학회
      • 박*서 : Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical dry granulation process, 2019 약제학회
      • 박*서 : Quality by Design (QbD) approach to optimize the formulation of a bilayer combination drug (Sapogrelate hydrochloride) composed with an immediate release layer and sustained release layer, 2018 약학회
    연락처
    • 연구실: 055-320-3395
    • 위치: 프라임의생명공학관 (J동) 연구실 402호
    졸업생 현황
    • 백*화 – 신일제약 연구소
    • 이*빈 – 신일제약 연구소
    • 염*빈 – 대원제약 연구소
    • 박*서 – 유유제약 연구소
    • 장*하 – 유유제약 연구소